Neurosolutions has been performing first class contract research since 2001 and continues to support the biopharmaceutical industry in developing new treatments for diseases occurring throughout the central and peripheral nervous system. Our particular strength in electrophysiology allows investigation of function in the naïve and diseased state at all levels of the neuraxis, and the contribution our data and knowledge have made, and continue to make, to drug development programs worldwide is significant.
Knowledge Transfer Partnership
Neurosolutions has received approximately £500K in grant funding for the commercialisation of academic know how through three separate 3 year programs;
- The development, validation and commercialisation of a new package of models to investigate stress/anxiety and depressive behaviours; University of Warwick Medical School
- The design, development and implementation of isolated tissue and behavioural models of learning/memory disorders; Queens University Belfast
- The development of murine models for pain; University of Warwick
Neurosolutions has sponsored two full-time PhD studentships over the past 8 years and continues to support new academic projects using internal resources and expertise, partnered with academic excellence at the University of Warwick, Monash University and elsewhere.
A small representation of the impact Neurosolutions has made to neuroscience research since 2001 can be demonstrated by some of our recent publications:
- A novel modulator of Ab aggregation: II e Reversal of Ab oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and miceAb oligomer toxicity inhibitor protects memory in models of synaptic toxicityActivation and integration of bilateral GABA-mediated synaptic inputs in neonatal rat sympathetic preganglionic neurones in vitroActivation of 5-HT1B and 5-HT1D receptors in the rat nucleus tractus solitarius: opposing action on neurones that receive an excitatory vagal C-fibre afferent inputActive and passive membrane properties of rat sympathetic preganglionic neurones innervating the adrenal medullaAltered circuit function and plasticity in the hippocampus and prefrontal cortex of an animal model of treatment-resistant depressionAnalysis of the Structure and Electrophysiological Actions of Halitoxins: 1,3 Alkyl-pyridinium Salts from Callyspongia ridleyBilaterally evoked monosynaptic EPSPs, NMDA receptors and potentiation in rat sympathetic preganglionic neurones in vitroCARBENOXOLONE DEPRESSES SPONTANEOUS EPILEPTIFORM ACTIVITY IN THE CA1 REGION OF RAT HIPPOCAMPAL SLICESCharacterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1Effect of pulmonary C-fibre afferent stimulation on cardiac vagal neurones in the nucleus ambiguus in anaesthetized catsEffects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivoElectrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivoElectrophysiological properties of electrical synapses between rat sympathetic preganglionic neurones in vitroELECTROPHYSIOLOGICAL, PHARMACOLOGICAL AND MOLECULAR PROFILE OF THE TRANSIENT OUTWARD RECTIFYING CONDUCTANCE IN RAT SYMPATHETIC PREGANGLIONIC NEURONS IN VITROELECTROPHYSIOLOGICAL, PHARMACOLOGICAL AND MOLECULAR PROFILE OF THE TRANSIENT OUTWARD RECTIFYING CONDUCTANCE IN RAT SYMPATHETIC PREGANGLIONIC NEURONS IN VITROEslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamideEXCITATION OF SYMPATHETIC PREGANGLIONIC NEURONS VIA METABOTROPIC EXCITATORY AMINO ACID RECEPTORSFeeding association between the nucleus of the solitary tract and the ventral tegmental areaFunctional reorganisation of synaptic activity and intrinsic membrane conductances in dorsal horn neurones of neuropathic rats and the effects of gabapentin in vitro.GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injuryHippocampal 5-HT7Histamine Excites Neonatal Rat Sympathetic Preganglionic Neurons In Vitro Via Activation of H1 ReceptorsImmunostaining for the α3 isoform of the Na+/K+-ATPase is selective for functionally identified muscle spindle afferents in vivoIn Vivo Electrophysiological Recording UNIT 11.15 Techniques for the Study of Neuropathic Pain in Rodent ModelsINHIBITION OF SYMPATHETIC PREGANGLIONIC NEURONS BY SPINAL GLYCINERGIC INTERNEURONSIntense Isolectin-B4 Binding in Rat Dorsal Root Ganglion Neurons Distinguishes C-Fiber Nociceptors with Broad Action Potentials and High Nav1.9 ExpressionMELATONIN GENERATES AN OUTWARD POTASSIUM CURRENT IN RAT SUPRACHIASMATIC NUCLEUS NEURONES IN VITRO INDEPENDENT OF THEIR CIRCADIAN RHYTHMNorepinephrine can Act via a2-Adrenoceptors to Reduce the Hyper-excitability of Spinal Dorsal Horn Neurons Following Chronic Nerve InjuryOrally bioavailable small molecule drug protects memory in Alzheimer’s disease modelsOrexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleusOrexins induce increased excitability and synchronisation of rat sympathetic preganglionic neuronesPartial nerve injury induces electrophysiological changes in conducting (uninjured) nociceptive and nonnociceptive DRG neurons: Possible relationships to aspects of peripheral neuropathic pain and paresthesiasPharmacodynamic Effects of a D-Amino Acid Oxidase Inhibitor Indicate a Spinal Site of Action in Rat Models of Neuropathic PainPHARMACOLOGICAL AND MOLECULAR CHARACTERIZATION OF ATP-SENSITIVE K CONDUCTANCES IN CART AND NPY/AgRP EXPRESSING NEURONS OF THE HYPOTHALAMIC ARCUATE NUCLEUSPharmacology of reflex blinks in the rat: a novel model for headache researchSeminars in Cell & Developmental Biology 17 (2006) 541–543 Introduction PainShort Photoperiod-Induced Decrease of Histamine H3 Receptors Facilitates Activation of Hypothalamic Neurons in the Siberian HamsterSpontaneous Pain, Both Neuropathic and Inflammatory, Is Related to Frequency of Spontaneous Firing in Intact C-Fiber NociceptorsSPONTANEOUS RHYTHMIC ACTIVITY IN THE INTERMEDIOLATERAL CELL NUCLEUS OF THE NEONATE RAT THORACOLUMBAR SPINAL CORD IN VITROTemperature dependence of erythromelalgia mutation L858F in Sodium channel NavThe N‑Methylated Peptide SEN304 Powerfully Inhibits Aβ(1−42) Toxicity by Perturbing Oligomer FormationThe Presence and Role of the Tetrodotoxin-Resistant Sodium Channel Nav1.9 (NaN) in Nociceptive Primary Afferent NeuronsThe role of central 5-HT3 receptors in vagal reflex inputs to neurones in the nucleus tractus solitarius of anaesthetized ratsThe role of sodium channels in neuropathic painThe TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neuronsTranslational PK–PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576