Specialists In Translational Preclinical Neuroscience Research Services

Pain

Neurosolutions has established expertise in delivering first class preclinical translational research into pain, particularly around the development of new treatments into neuropathic and inflammatory pain.

Our track record can be demonstrated in our manuscript publications and our key strength is in developing precisely tailored research packages to target out client’s needs. Whether through using in vitro or in vivo electrophysiological approaches to establish mechanism, using whole animal behavior in one of our many pain models to screen compounds, or using molecular biology techniques to better understand function, our research teams will provide expert consultancy in putting together the study proposal you require, and our investigators will then rapidly deliver data of the highest quality to drive forward your research programs.

pain

Relevant Neurosolutions Publications:

Pain Models Behavioural Read-outs Electrophysiological Assays
  • Chronic constriction injury
  • Spinal nerve ligation
  • Diabetes-induced
  • Chemotherapy-induced
  • Fracture pain model
  • Carrageenan
  • Complete Freund’s adjuvant
  • Formalin
  • MIA
  • UVB
  • Surgical pain
  • Von Frey hair
  • Hargreave’s
  • Randall-Selitto
  • Weight-bearing
  • Paw licking, shaking, lifting
  • Plethysmography
  • RotaRod test

In vivo: Single fibre recording, spontaneous and evoked, single neurone recording from the spinal cord and brain, all naïve and modelled animals

In vitro: Compound action potential recording from isolated nerves, naïve and modelled, slice patch-clamp recordings, dissociated DRG patch-clamp recordings from naïve and modelled animals

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