Specialists In Translational Preclinical Neuroscience Research Services

Neurodegeneration

Neurosolutions has extensive experience in delivering first class preclinical translational research into the study, treatment and prevention of neurodegenerative disorders, particularly around amyloid based animal models of Alzheimer’s disease.

Our track record is demonstrated in our manuscript publications and our key strength is in developing precisely tailored research packages to target out client’s needs. Whether it is in vitro or in vivo electrophysiological approaches, whole animal behavior or molecular biology techniques, our research teams will provide expert consultancy in putting together the study proposal you require, and our investigators will then rapidly deliver data of the highest quality to drive forward your research programs.

neurodegeneration

Relevant Neurosolutions Publications:

Disease Areas Behavioural Tests Electrophysiological Assays
  • Alzheimer’s Disease
  • Parkinson’s Disease
  • Multiple Sclerosis
  • Huntington’s Disease
  • Open field: e.g. object recognition test (ORT), Y-maze, Barnes maze
  • Operant chambers: e.g. Alternating Lever Cyclic Ratio (ALCR), delayed match-to-position (DMTP/DNMTP)
  • Beta-amyloid induced deficits (ADDL/APP/oligomers/aggregated) α-synuclein-induced deficits
  • Commercially available transgenic rodent models

In vivo: single cells – extra and intracellular recording; iontophoretic, central and parenteral drug administration

Local field potentials – spontaneous and evoked, including LTP/LTD

Peripheral nerves – compound and single fibre

Telemetric and multi-electrode recording

In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised)

Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA)

Ion channel pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines

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